Trial Design in Respiratory Disease Based on the Win Probability

Documentation for package ‘ISPYARDSWinProbabilityGSDesign’ version 0.1.0

CONTROL_ADVANCED_DISTRIBUTION_NO_VENT	Example of a non-parametric density estimate of advanced respiratory days in participants who were never ventilated used for simulation.
CONTROL_ADVANCED_DISTRIBUTION_VENT	Example of a non-parametric density estimate of advanced respiratory days in participants who were ventilated used for simulation.
CONTROL_VENT_DENSITY_NON_0_28	Example of a non-parametric density estimate of ventilator days used for simulation.
Example_Data	Example of dataset used for the I-SPY ARDS win hierarchy
Get_ARDS_Win_Probability	Provides analysis results related to the I-SPY ARDS composite ranking.
Get_True_Win_Probability	Gives the true win probability, mean ventilator days, and advanced respiratory days for a set of simulation parameters.
Sim_ARDS_Win_Probability	Provides operating characteristics for a group sequential design using the I-SPY ARDS hierarchical composite ranked endpoint and gating strategy with gating strategy and Bayesian Wilcoxon Rank-Sum test.