Package: NNTbiomarker
Type: Package
Title: Calculate Design Parameters for Biomarker Validation Studies
Version: 0.29.11
Date: 2015-08-20
Author: Roger Day
Maintainer: Roger Day <day01@pitt.edu>
Description: Helps a clinical trial team  discuss
    the clinical goals  of a well-defined biomarker with a diagnostic,
    staging, prognostic, or predictive purpose.  From this discussion will
    come a statistical plan for a (non-randomized) validation trial.
    Both prospective and retrospective trials are supported. In a specific
    focused discussion, investigators should determine the range of
    "discomfort" for the NNT, number needed to treat.  The meaning of
    the discomfort range, [NNTlower, NNTupper], is that within this range
    most physicians would feel discomfort either in treating or withholding
    treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg,
    become the targets of the study's design.  If the trial can demonstrate
    that a positive biomarker test yields an NNT less than NNTlower,
    and that a negative biomarker test yields an NNT less than NNTlower,
    then the biomarker may be useful for patients. A highlight of the package
    is visualization of a "contra-Bayes" theorem, which produces criteria for
    retrospective case-controls studies.
License: GPL-3
Imports: shiny, xtable, stringr, magrittr, mvbutils
Collate: aaa.R ifVerboseCat.R sesp-pv-NNT.R achievable.se.sp.R
        binom.confint.R NNTintervals.R run.R ROCplots.R argmin.R zzz.R
Suggests: testthat (>= 0.8.1), knitr (>= 1.6), rmarkdown, ggplot2, plyr
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2015-08-20 20:36:16 UTC; Roger
Repository: CRAN
Date/Publication: 2015-08-21 07:38:39
Built: R 4.0.2; ; 2020-07-16 19:50:49 UTC; unix
